

| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 11:28pm CT |
| Started | TE | Mike Gesicki CIN | Owner | Wed Nov 26 11:28pm CT |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 26 4:29pm CT |
| Started | QB | Lamar Jackson BAL | Owner | Wed Nov 26 4:29pm CT |
| Benched | QB | Lamar Jackson BAL | Owner | Tue Nov 25 6:27am CT |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 25 6:27am CT |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 6:27am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:27am CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Fri Nov 28 12:46pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Fri Nov 28 12:46pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 25 9:49pm CT |
| Started | RB | Chase Brown CIN | Owner | Tue Nov 25 9:49pm CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 8:06am CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 8:06am CT |
| Benched | RB | Bucky Irving TB | Owner | Thu Nov 27 9:40am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Thu Nov 27 9:40am CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 6:26pm CT |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 6:26pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 6:26pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 6:26pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:26pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:26pm CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Fri Nov 28 11:57am CT |
| Benched | TE | Theo Johnson NYG | Owner | Fri Nov 28 11:57am CT |
| Started | WR | Deebo Samuel WAS | Owner | Fri Nov 28 11:57am CT |
| Started | TE | Cade Otton TB | Owner | Fri Nov 28 11:57am CT |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 10:34pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 10:34pm CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 10:34pm CT |
| Benched | K | Chase McLaughlin TB | Owner | Tue Nov 25 10:34pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:34pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 10:34pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 10:34pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 10:34pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 7:04am CT |
| Started | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 7:04am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 5:47pm CT |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 5:47pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 5:47pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 5:47pm CT |
| No starting lineup changes performed this week. |
| Started | D/ST | Indianapolis Colts IND | Owner | Thu Nov 27 8:56am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 11:39pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 11:39pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 11:39pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 11:39pm CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 5:16pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 5:16pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 5:16pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 5:16pm CT |
| Started | K | Riley Patterson MIA | Owner | Thu Nov 27 5:19am CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 7:12pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 7:12pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 10:03am CT |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 26 10:03am CT |