

| Benched | RB | Emanuel Wilson GB | Commissioner | Thu Nov 27 1:07pm ET |
| Started | RB | Kenneth Gainwell PIT | Commissioner | Thu Nov 27 1:07pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Fri Nov 28 9:35am ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Fri Nov 28 9:35am ET |
| Started | WR | Romeo Doubs GB | Owner | Thu Nov 27 12:28pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Thu Nov 27 12:28pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 6:08am ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 6:08am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 25 9:27am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:27am ET |
| Started | WR | Luther Burden III CHI | Owner | Tue Nov 25 9:27am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 9:27am ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 9:27am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 9:27am ET |
| Benched | TE | Sam LaPorta DET | Owner | Wed Nov 26 6:13pm ET |
| Started | TE | Hunter Henry NE | Owner | Wed Nov 26 6:13pm ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 9:55am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 9:55am ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 9:55am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 9:55am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:55am ET |
| Started | K | Harrison Butker KC | Owner | Tue Nov 25 9:55am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 4:08am ET |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 12:34pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 12:34pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 1:18pm ET |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 1:18pm ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 25 1:18pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 1:18pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:18pm ET |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 1:18pm ET |
| No starting lineup changes performed this week. |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 1:39pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Fri Nov 28 1:39pm ET |
| Started | RB | Rico Dowdle CAR | Owner | Thu Nov 27 3:07am ET |
| Benched | WR | Terry McLaurin WAS | Owner | Thu Nov 27 3:07am ET |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 3:07am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Thu Nov 27 3:07am ET |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 3:03am ET |
| Benched | TE | Dalton Schultz HOU | Owner | Thu Nov 27 3:03am ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 2:38am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 2:38am ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 25 2:00pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 2:00pm ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 1:58pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 1:58pm ET |
| Benched | RB | Devin Neal NO | Owner | Fri Nov 28 10:55am ET |
| Started | WR | Jakobi Meyers JAX | Owner | Fri Nov 28 10:55am ET |
| Benched | WR | Quentin Johnston LAC | Owner | Thu Nov 27 12:14pm ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 12:14pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 8:53am ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 8:53am ET |
| Benched | D/ST | New Orleans Saints NO | Owner | Tue Nov 25 11:05am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 25 11:05am ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 3:33pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 2:55pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 2:55pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 1:22pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 1:22pm ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 1:22pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 1:22pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:22pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 1:22pm ET |
| Started | TE | Evan Engram DEN | Owner | Thu Nov 27 4:07am ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 7:02pm ET |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 7:02pm ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 1:13pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 1:13pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 6:36pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 6:36pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Nov 25 6:36pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 6:36pm ET |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 25 8:17am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:17am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:17am ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 8:17am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:17am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 25 8:17am ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 10:23pm ET |
| Started | RB | Rachaad White TB | Owner | Wed Nov 26 10:23pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 11:33am ET |
| Benched | WR | Sterling Shepard TB | Owner | Wed Nov 26 11:33am ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 11:33am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 11:33am ET |