

| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 8:14pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 25 8:14pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 8:13pm ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 8:13pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 25 8:13pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 8:13pm ET |
| Started | K | Harrison Mevis LAR | Owner | Thu Nov 27 11:28am ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 26 4:07pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:07pm ET |
| Started | RB | Travis Etienne JAX | Owner | Wed Nov 26 4:07pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 4:07pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 11:40am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 11:40am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 5:42pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 5:42pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 5:42pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:42pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Thu Nov 27 10:31am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 10:31am ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 10:47am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 10:47am ET |
| No starting lineup changes performed this week. |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 1:47pm ET |
| Started | TE | Terrance Ferguson LAR | Owner | Thu Nov 27 1:47pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 8:57am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 8:57am ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Wed Nov 26 8:57am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 8:57am ET |
| Benched | QB | Geno Smith LV | Owner | Thu Nov 27 5:47am ET |
| Started | QB | Aaron Rodgers PIT | Owner | Thu Nov 27 5:47am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 8:41am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:41am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:41am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:41am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 11:30am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 11:30am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Ray Davis BUF | Owner | Fri Nov 28 7:44pm ET |
| Started | RB | Brian Robinson Jr. SF | Owner | Fri Nov 28 7:44pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 11:56pm ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 11:56pm ET |
| Started | RB | Ray Davis BUF | Owner | Tue Nov 25 11:56pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:56pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 2:39am ET |
| Benched | D/ST | New England Patriots NE | Owner | Wed Nov 26 2:39am ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:39am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 2:39am ET |