

| Benched | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 7:23pm ET |
| Started | WR | Chris Godwin TB | Owner | Fri Nov 28 7:23pm ET |
| Benched | WR | Pat Bryant DEN | Owner | Thu Nov 27 12:42am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 12:42am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 7:55pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 7:55pm ET |
| Started | QB | Caleb Williams CHI | Owner | Tue Nov 25 7:55pm ET |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 25 7:55pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 11:10am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 11:10am ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 25 11:35am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 11:35am ET |
| Started | TE | Isaiah Likely BAL | Owner | Wed Nov 26 7:29pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 7:29pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 12:35pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 12:35pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 12:35pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 12:35pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 12:35pm ET |
| Benched | D/ST | San Francisco 49ers SF | Owner | Tue Nov 25 12:35pm ET |
| Benched | K | Michael Badgley IND | Owner | Tue Nov 25 12:35pm ET |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 12:35pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 12:35pm ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 12:35pm ET |
| Benched | WR | Marquise Brown KC | Owner | Thu Nov 27 12:57pm ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 12:57pm ET |
| Started | WR | Justin Jefferson MIN | Owner | Thu Nov 27 8:36am ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 8:39am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 8:39am ET |
| Benched | WR | Justin Jefferson MIN | Owner | Tue Nov 25 8:39am ET |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 25 8:39am ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 8:39am ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 8:39am ET |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 25 8:39am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 5:48pm ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 5:48pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 5:48pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 5:48pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Khalil Shakir BUF | Owner | Wed Nov 26 11:04pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 11:04pm ET |
| Benched | QB | Drake Maye NE | Owner | Tue Nov 25 11:19am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 25 11:19am ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 6:05pm ET |
| Benched | D/ST | Houston Texans HOU | Owner | Tue Nov 25 6:05pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 6:05pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 25 6:05pm ET |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 6:51am ET |
| Started | RB | Jeremy McNichols WAS | Owner | Wed Nov 26 6:51am ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 25 7:18am ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 7:18am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 7:18am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:18am ET |