

| Benched | WR | Chris Olave NO | Owner | Thu Nov 27 8:27am ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 27 8:27am ET |
| Benched | WR | Khalil Shakir BUF | Owner | Wed Nov 26 10:22am ET |
| Benched | LB | Lavonte David TB | Owner | Wed Nov 26 10:22am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 10:22am ET |
| Started | LB | Bobby Wagner WAS | Owner | Wed Nov 26 10:22am ET |
| Benched | LB | Nick Bolton KC | Owner | Thu Nov 27 7:54am ET |
| Started | LB | Tyrel Dodson MIA | Owner | Thu Nov 27 7:54am ET |
| Benched | TE | Theo Johnson NYG | Owner | Thu Nov 27 7:48am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 7:48am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 8:12pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 8:12pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 12:36pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 12:36pm ET |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 8:09am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 8:09am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 8:09am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 8:09am ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:45pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 3:45pm ET |
| Started | LB | Bobby Wagner WAS | Owner | Tue Nov 25 3:44pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Tue Nov 25 3:44pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 3:44pm ET |
| Benched | LB | Terrel Bernard BUF | Owner | Tue Nov 25 3:44pm ET |
| Benched | TE | Brenton Strange JAX | Owner | Tue Nov 25 3:44pm ET |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 3:44pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 27 8:43am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 8:43am ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 8:41am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Stefon Diggs NE | Owner | Wed Nov 26 8:43am ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 8:43am ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 8:35am ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 8:35am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Thu Nov 27 9:01am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 9:01am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 1:16pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 1:16pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 1:16pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Tue Nov 25 1:16pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 9:53pm ET |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 9:53pm ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 9:53pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 9:53pm ET |
| Started | LB | Jordyn Brooks MIA | Owner | Thu Nov 27 12:12pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Thu Nov 27 12:11am ET |
| Started | RB | Isiah Pacheco KC | Owner | Thu Nov 27 12:11am ET |
| Benched | WR | Chris Godwin TB | Owner | Thu Nov 27 12:10am ET |
| Started | WR | Tez Johnson TB | Owner | Thu Nov 27 12:10am ET |
| Started | K | Los Angeles Chargers LAC | Owner | Thu Nov 27 5:13pm ET |
| Started | LB | Demetrius Knight Jr. CIN | Owner | Thu Nov 27 11:55am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 9:44pm ET |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 9:44pm ET |
| Started | WR | Romeo Doubs GB | Owner | Wed Nov 26 9:44pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:44pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Thu Nov 27 1:52pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 1:52pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 1:52pm ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 1:52pm ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 8:34pm ET |
| Started | QB | Baker Mayfield TB | Owner | Wed Nov 26 8:34pm ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 1:45pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Wed Nov 26 1:45pm ET |
| Benched | LB | Pete Werner NO | Owner | Wed Nov 26 1:45pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 1:45pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 1:45pm ET |
| Started | LB | Frankie Luvu WAS | Owner | Wed Nov 26 1:45pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 9:07pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 9:07pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:53pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Tue Nov 25 6:53pm ET |
| Started | LB | Tyrel Dodson MIA | Owner | Tue Nov 25 2:13pm ET |
| Started | K | Los Angeles Chargers LAC | Owner | Tue Nov 25 2:13pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 2:13pm ET |
| Started | QB | Lamar Jackson BAL | Owner | Tue Nov 25 2:13pm ET |
| Benched | LB | Dee Winters SF | Owner | Tue Nov 25 2:13pm ET |
| Benched | K | Buffalo Bills BUF | Owner | Tue Nov 25 2:13pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 2:13pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 2:13pm ET |
| Benched | LB | Quincy Williams NYJ | Owner | Thu Nov 27 10:22pm ET |
| Started | LB | Germaine Pratt IND | Owner | Thu Nov 27 10:22pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 10:32pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 10:32pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 9:28am ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 9:28am ET |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 9:28am ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 9:28am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 11:24pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 11:24pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 11:24pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:24pm ET |
| Started | RB | Michael Carter ARI | Owner | Fri Nov 28 1:42pm ET |
| Benched | RB | Jaleel McLaughlin DEN | Owner | Fri Nov 28 1:42pm ET |
| Started | RB | Jaleel McLaughlin DEN | Owner | Fri Nov 28 1:41pm ET |
| Benched | RB | Trey Benson ARI | Owner | Fri Nov 28 1:41pm ET |
| Started | LB | Jordyn Brooks MIA | Owner | Tue Nov 25 8:47am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:47am ET |
| Started | RB | Trey Benson ARI | Owner | Tue Nov 25 8:47am ET |
| Benched | LB | Ruben Hyppolite II CHI | Owner | Tue Nov 25 8:47am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 8:47am ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:47am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 6:15pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 6:15pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 6:14pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 6:14pm ET |
| Benched | WR | Sterling Shepard TB | Owner | Thu Nov 27 11:01am ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 11:01am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 11:23pm ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 11:23pm ET |
| Benched | DB | Brian Branch DET | Owner | Tue Nov 25 11:23pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 11:23pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 11:23pm ET |
| Started | DB | Derwin James LAC | Owner | Tue Nov 25 11:23pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 25 9:20am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 9:20am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 9:19am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 9:19am ET |
| Benched | LB | Devin White LV | Owner | Tue Nov 25 9:19am ET |
| Started | RB | Trey Benson ARI | Owner | Tue Nov 25 9:19am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:19am ET |
| Started | LB | Daiyan Henley LAC | Owner | Tue Nov 25 9:19am ET |
| Benched | WR | Jameson Williams DET | Owner | Thu Nov 27 12:43pm ET |
| Benched | TE | Elijah Arroyo SEA | Owner | Thu Nov 27 12:43pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:43pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 12:43pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 10:45pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 10:45pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 10:45pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 10:45pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 10:45pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 10:45pm ET |
| No starting lineup changes performed this week. |