

| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 1:33pm ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 1:33pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Thu Nov 27 2:15pm ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 2:15pm ET |
| Benched | RB | Bucky Irving TB | Owner | Thu Nov 27 2:12pm ET |
| Started | TE | Mike Gesicki CIN | Owner | Thu Nov 27 2:12pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 6:29pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:29pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 12:08am ET |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 12:08am ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 12:06am ET |
| Benched | WR | Zay Flowers BAL | Owner | Thu Nov 27 12:06am ET |
| Benched | TE | Mason Taylor NYJ | Owner | Thu Nov 27 12:06am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 12:06am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 12:06am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:06am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 7:47am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 7:47am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 7:47am ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 7:47am ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 9:13pm ET |
| Benched | DEF | Arizona Cardinals ARI | Owner | Tue Nov 25 9:13pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:13pm ET |
| Started | DEF | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 9:13pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 12:37pm ET |
| Benched | DEF | Atlanta Falcons ATL | Owner | Thu Nov 27 12:37pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 12:37pm ET |
| Started | DEF | Jacksonville Jaguars JAX | Owner | Thu Nov 27 12:37pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 9:50am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 9:50am ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 10:53am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 10:53am ET |
| Benched | TE | AJ Barner SEA | Owner | Thu Nov 27 10:53am ET |
| Started | RB | Kyle Monangai CHI | Owner | Thu Nov 27 10:53am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 10:53am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 10:53am ET |
| Benched | DEF | Dallas Cowboys DAL | Owner | Wed Nov 26 10:27pm ET |
| Started | DEF | Denver Broncos DEN | Owner | Wed Nov 26 10:27pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 9:26am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 9:26am ET |
| Benched | ST | San Francisco 49ers SF | Owner | Thu Nov 27 12:16pm ET |
| Started | ST | Denver Broncos DEN | Owner | Thu Nov 27 12:16pm ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 4:56pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:56pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Daniel Jones IND | Owner | Fri Nov 28 1:44pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Fri Nov 28 1:44pm ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 7:57am ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 7:57am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 1:14pm ET |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Sat Nov 29 1:14pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 1:39pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 1:39pm ET |
| Started | DEF | Indianapolis Colts IND | Owner | Tue Nov 25 3:34pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:34pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 3:34pm ET |
| Benched | DEF | Pittsburgh Steelers PIT | Owner | Tue Nov 25 3:34pm ET |
| Benched | WR | Chris Godwin TB | Owner | Tue Nov 25 3:34pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 3:34pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Caleb Williams CHI | Owner | Fri Nov 28 11:46am ET |
| Started | QB | Jaxson Dart NYG | Owner | Fri Nov 28 11:46am ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 12:30am ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 12:30am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 8:13am ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 8:13am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:13am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 8:13am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 9:24am ET |
| Benched | DEF | Carolina Panthers CAR | Owner | Tue Nov 25 9:24am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:24am ET |
| Started | DEF | Los Angeles Chargers LAC | Owner | Tue Nov 25 9:24am ET |